Oak Ridge Today

Roane State graduate doing climate change research at ORNL

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Rachel Andrews, a graduate of Roane State, is shown in an Oak Ridge National Laboratory lab getting serum bottles ready for an incubation experiment. (Photo courtesy Lynn Freeny/U.S. Department of Energy)

By Bob Fowler, Roane State staff writer

A recent Roane State Community College graduate is researching climate change and the microorganisms that contribute to it.

Rachel Andrews, a Morgan County resident who graduated from the community college in May 2019, is an intern at Oak Ridge National Laboratory. She’s doing research with Christopher Schadt in the Biosciences Division at the lab.

They are investigating methane production in peat, which is formed by the partial decomposition of plants in wet, acidic conditions of bogs. Scientists say methane gas is one of the major contributors to a warming planet.

“We study the methanogens that live in peatland soil,” Andrews said in an emailed response to questions about her research. She said these microorganisms produce quite a bit of methane and carbon dioxide, also identified as a culprit in climate change.

[Read more…]

New ORNL tool probes for genes linked to toxic methyl mercury, could help Y-12 cleanup

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ORNL Andrew King Mercury Methylation Genes

Andrew King loads a gel with amplified gene fragments to detect the presence of mercury methylation genes in samples from East Fork Poplar Creek in Oak Ridge. (Photo by ORNL)

 

Environmental scientists can more efficiently detect genes required to convert mercury in the environment into more toxic methylmercury with molecular probes developed by researchers at the U.S. Department of Energy’s Oak Ridge National Laboratory. The research could help the cleanup work at the Y-12 National Security Complex.

“We now have a quick and easy-to-use tool that we can employ in any environment to test for the presence of microorganisms capable of methylating mercury and determine how abundant they are,” said ORNL’s Geoff Christensen, a post-doc and lead author of a paper published in Applied and Environmental Microbiology.

In 2013, ORNL researchers reported in Science on the discovery of two genes known to transform inorganic mercury into its highly toxic organic form. Development of the newly validated probes further advances research to protect human health, a press release said.

For this study, researchers tested the probes against 31 strains of microorganisms for which they know the ones that produce methylmercury and scored a 94 percent confirmation rate, the press release said. This validation procedure is critical to the next step of moving the probes into the field to help determine the amount of methylmercury likely to be generated in any given environment. [Read more…]

ORNL cell-free protein synthesis is potential lifesaver

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Nanoporous-Membrane-December-2015-ORNL

This section of a serpentine channel reactor shows the parallel reactor and feeder channels separated by a nanoporous membrane. At left is a single nanopore viewed from the side; at right is a diagram of metabolite exchange across the membrane. (Image by ORNL)

 

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the U.S. Department of Energy’s Oak Ridge National Laboratory.

The device, a creation of a team led by Andrea Timm and Scott Retterer of the lab’s Biosciences Division, uses microfabricated bioreactors to help the on-demand production of therapeutic proteins for medicines and biopharmaceuticals. Making these miniature factories cell-free, which eliminates the maintenance of a living system, simplifies the process and lowers cost.

“With this approach, we can produce more protein faster, making our technology ideal for point-of-care use,” Retterer said. “The fact it’s cell-free reduces the infrastructure needed to produce the protein and opens the possibility of creating proteins when and where you need them, bypassing the challenge of keeping the proteins cold during shipment and storage.” [Read more…]

ORNL researchers Simpson, Snead, Tuskan named corporate fellows

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ORNL Corporate Fellows Michael Simpson, Lance Snead, and Gerald Tuskan

Michael L. Simpson, Lance L. Snead, and Gerald A. Tuskan have been named corporate fellows of the U.S. Department of Energy’s Oak Ridge National Laboratory. (Photo courtesy ORNL)

Michael L. Simpson, Lance L. Snead, and Gerald A. Tuskan have been named corporate fellows of the U.S. Department of Energy’s Oak Ridge National Laboratory.

Among the lab’s highest honors, the corporate fellow designation recognizes the researchers’ significant accomplishments and continuing leadership in their scientific, engineering, and technological fields. With their addition, the number of active corporate fellows at ORNL is now 29 researchers, a press release said.

“Our new corporate fellows—Mike, Lance, and Jerry—are recognized leaders in the fields of nanotechnology, materials research, and bioscience, respectively,” ORNL Director Thom Mason said. “Their careers represent the span of ORNL research from fundamental science to real-world technologies for the nation’s critical needs in energy and the environment.” [Read more…]

UT, ORNL scientists’ discoveries could help neutralize chemical weapons

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Enzyme Figure

Nerve agent sarin bound to bioscavenger enzyme. (Image courtesy University of Tennessee)

KNOXVILLE—Researchers at the University of Tennessee and Oak Ridge National Laboratory are a step closer to creating a prophylactic drug that would neutralize the deadly effects of the chemical weapons used in Syria and elsewhere.

Jeremy Smith, UT-ORNL Governor’s Chair and an expert in computational biology, is part of the team that is trying to engineer enzymes—called bioscavengers—so they work more efficiently against chemical weapons. The work is a joint effort between scientists at UT, ORNL, and a French national laboratory in Grenoble. Their study was published recently in the Journal of Physical Chemistry.

Nerve agents, such as sarin, are among the most highly toxic chemical weapons. The study focuses on engineering enzymes that catalyze the hydrolysis of nerve agents as a prophylactic approach to diminishing their toxic effects. [Read more…]

UT names bioenergy expert as 14th UT-ORNL Governor’s Chair

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Art Ragauskas

Arthur Ragauskas

KNOXVILLE—Arthur Ragauskas, an authority in bioenergy, has been named the 14th University of Tennessee-Oak Ridge National Laboratory Governor’s Chair.

He will serve as Governor’s Chair for Biorefining, based in UT’s Department of Chemical and Biomolecular Engineering with a complementary appointment in the UT Institute of Agriculture’s Department of Forestry, Wildlife, and Fisheries.

He will also serve in the Energy and Environmental Sciences Directorate, Biosciences Division, at ORNL and as a member of the U.S. Department of Energy’s BioEnergy Science Center, or BESC.

Ragauskas begins at UT on June 1. [Read more…]

ORNL: Toxic methylmercury-producing microbes more widespread than realized

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Microbes that live in rice paddies, northern peat bogs, and other previously unexpected environments are among the bacteria that can generate highly toxic methylmercury, researchers at Oak Ridge National Laboratory and the Smithsonian Environmental Research Center have learned.

This finding, published in Environmental Science and Technology, explains why deadly methylated mercury is produced in areas where the neurotoxin’s presence has puzzled researchers for decades. Methylmercury—the most dangerous form of mercury—damages the brain and immune system and is especially harmful to developing embryos. Certain bacteria transform inorganic mercury into toxic methylmercury. [Read more…]