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ORNL cell-free protein synthesis is potential lifesaver

Posted at 10:47 am January 3, 2016
By Oak Ridge National Laboratory Leave a Comment

Nanoporous-Membrane-December-2015-ORNL

This section of a serpentine channel reactor shows the parallel reactor and feeder channels separated by a nanoporous membrane. At left is a single nanopore viewed from the side; at right is a diagram of metabolite exchange across the membrane. (Image by ORNL)

 

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the U.S. Department of Energy’s Oak Ridge National Laboratory.

The device, a creation of a team led by Andrea Timm and Scott Retterer of the lab’s Biosciences Division, uses microfabricated bioreactors to help the on-demand production of therapeutic proteins for medicines and biopharmaceuticals. Making these miniature factories cell-free, which eliminates the maintenance of a living system, simplifies the process and lowers cost.

“With this approach, we can produce more protein faster, making our technology ideal for point-of-care use,” Retterer said. “The fact it’s cell-free reduces the infrastructure needed to produce the protein and opens the possibility of creating proteins when and where you need them, bypassing the challenge of keeping the proteins cold during shipment and storage.” [Read more…]

Filed Under: Front Page News, Oak Ridge National Laboratory, U.S. Department of Energy Tagged With: Andrea Timm, bioreactor, Biosciences Division, Carmen Foster, Center for Nanophase Materials Sciences, DOE, DOE Office of Science, electron beam, Funding for this project was provided by the Defense Advanced Research Projects Agency, Leidos, microfabricated bioreactors, Mitchel Doktycz, nanoporous membrane, National Institutes of Health, Northwestern University, Oak Ridge National Laboratory, Peter Shankles, photolithography, Scott Retterer, Small, therapeutic proteins, Towards Microfluidic Reactors for Cell-Free Protein Synthesis at the Point-of-Care, U.S. Department of Energy

Traffic Safety, Environmental Advisory board member running for City Council

Posted at 9:42 pm October 24, 2014
By Oak Ridge Today Staff Leave a Comment

Aditya "Doc" Savara

Aditya “Doc” Savara

Aditya “Doc” Savara, a member of two city boards, is running for Oak Ridge City Council in the November 4 municipal election.

In a press release, Savara said he has been involved in local politics during the past two years and served on the Traffic Safety Advisory Board and the Environmental Quality Advisory Board. Savara said he has attended and commented during public comment periods at City Council meetings, is knowledgeable about the issues facing the city, and has been vocal about them.

“In 2012-2013, an ordinance came before Oak Ridge City Council regarding whether property owners Jack and Myra Mansfield could build a single home on their property in a neighborhood zoned as R1, for single-family dwellings,” Savara said in the release. “Adjacent homeowners asserted property values would drop if the Mansfields were allowed to build a home on the open space. I pointed out that the neighbors could have bought the open property themselves if they wanted to keep it as open space. I stated that the neighbors didn’t want to buy the cow, but wanted to have the milk for free, and that it was not too late for the neighbors to make the Mansfields a fair offer. [Read more…]

Filed Under: 2014 Election, Government, Oak Ridge, Top Stories Tagged With: Aditya "Doc" Savara, apartments, Board of Education, Centennial Golf Course, City Council, Doc Savara, economy, Environmental Quality Advisory Board, golf course, incentives, Jack Mansfield, lease, manufacturing, Myra Mansfield, Northwestern University, Oak Ridge, Oak Ridge Chamber of Commerce, open space, recycling, retail, shopping centers, strip malls, taxes, teaching, Traffic Safety Advisory Board

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Classifieds

Public Notice: NNSA announces no significant impact of Y-12 Development Organization operations at Horizon Center

AVAILABILITY OF THE FINAL ENVIRONMENTAL ASSESSMENT FOR THE OFFSITE HOUSING OF THE Y-12 DEVELOPMENT … [Read More...]

ADFAC seeks contractors for five homes

Aid to Distressed Families of Appalachian Counties (ADFAC) is a non-profit community based agency, … [Read More...]

Public notice: Draft environmental assessment for Y-12 Development Organization at Horizon Center

AVAILABILITY OF THE DRAFT ENVIRONMENTAL ASSESSMENT FOR THE OFFSITE HOUSING OF THE Y-12 DEVELOPMENT … [Read More...]

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