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ORNL cell-free protein synthesis is potential lifesaver

Posted at 10:47 am January 3, 2016
By Oak Ridge National Laboratory Leave a Comment

Nanoporous-Membrane-December-2015-ORNL

This section of a serpentine channel reactor shows the parallel reactor and feeder channels separated by a nanoporous membrane. At left is a single nanopore viewed from the side; at right is a diagram of metabolite exchange across the membrane. (Image by ORNL)

 

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the U.S. Department of Energy’s Oak Ridge National Laboratory.

The device, a creation of a team led by Andrea Timm and Scott Retterer of the lab’s Biosciences Division, uses microfabricated bioreactors to help the on-demand production of therapeutic proteins for medicines and biopharmaceuticals. Making these miniature factories cell-free, which eliminates the maintenance of a living system, simplifies the process and lowers cost.

“With this approach, we can produce more protein faster, making our technology ideal for point-of-care use,” Retterer said. “The fact it’s cell-free reduces the infrastructure needed to produce the protein and opens the possibility of creating proteins when and where you need them, bypassing the challenge of keeping the proteins cold during shipment and storage.” [Read more…]

Filed Under: Front Page News, Oak Ridge National Laboratory, U.S. Department of Energy Tagged With: Andrea Timm, bioreactor, Biosciences Division, Carmen Foster, Center for Nanophase Materials Sciences, DOE, DOE Office of Science, electron beam, Funding for this project was provided by the Defense Advanced Research Projects Agency, Leidos, microfabricated bioreactors, Mitchel Doktycz, nanoporous membrane, National Institutes of Health, Northwestern University, Oak Ridge National Laboratory, Peter Shankles, photolithography, Scott Retterer, Small, therapeutic proteins, Towards Microfluidic Reactors for Cell-Free Protein Synthesis at the Point-of-Care, U.S. Department of Energy

AC wins district volleyball championship, OR is runner-up; both advance to region

Posted at 12:10 am October 11, 2015
By John Huotari Leave a Comment

Anderson County Lady Mavericks District 3-AAA Volleyball Champions 2015

The Anderson County Lady Mavericks, pictured above, won the 2015 District 3-AAA volleyball championship, beating Oak Ridge 3-1 at Halls on Wednesday, Oct. 7, 2015. Both teams advance to the Region 2 tournament that starts Tuesday at ACHS. (Photo by John Huotari/Oak Ridge Today)

 

Note: This story was last updated at 12:35 p.m.

HALLS—The Anderson County Lady Mavericks won the District 3-AAA volleyball championship on Wednesday, beating Oak Ridge 3-1. Both teams advance to the Region 2-AAA tournament that starts Tuesday at Anderson County High School.

The Lady Wildcats, who finished as District 3-AAA runner-up, won their semifinal games 3-1 over Halls earlier Wednesday, while the Lady Mavericks swept Gibbs 3-0.

Anderson County’s one loss to Oak Ridge in the final round on Wednesday was the first district loss for the Lady Mavericks this season. They won the first two games 25-18 and 25-8, but then lost the third one 26-28.

The girls fell into a lull in the third game, but erased that from their minds and started over in the fourth match, Lady Mavericks Coach Jayme Smith said. They won the fourth game 25-11. Winning teams had to win three of the five potential games. [Read more…]

Filed Under: Front Page News, High School, Slider, Sports, Sports Tagged With: Alex Sherles, Anderson County High School, Brooke Carter, Carmen Foster, Colebee Sumner, District 3-AAA, Emilee Sturgill, Emily Lawless, Emma Milloway, Halls, Jayme Smith, Lady Mavericks, Lady Wildcats, Maddy Taylor, Oak Ridge, Reagan Dickens, Region 2-AAA, Taylor Payne, volleyball

Updated: Oak Ridge sunk by Admirals; Farragut wins Region 2 tournament

Posted at 12:52 am October 15, 2014
By Trenton Duffer Leave a Comment

Mattie Livengood of Oak Ridge, and Anne Abernathy and Alexis Parker of Farragut

At left, Mattie Livengood of Oak Ridge, the District 3 champions, goes up against defenders Anne Abernathy (11) and Alexis Parker (6) of Farragut, the Region 4 runner-up, during semifinals at the Region 2-AAA championship at Bearden High School on Tuesday. Farragut beat Oak Ridge and went on to win the regional championship in the finals match against Bearden. (Photos by Nicholas Rhodes)

 

Note: This story was updated with stats at 10:10 a.m. Oct. 16.

BEARDEN—The first matchup of the night featured the Oak Ridge Lady Wildcats battling the Farragut Lady Admirals. Oak Ridge fought hard against Farragut, but was eventually beaten in straight sets: 25-8, 25-10, and 25-11.

The first set was all Farragut. After putting up the first six points of the set, the Lady Admirals kept piling on the score. At one point of the set, they commanded a 15-3 lead on the Lady Wildcats. Before the Wildcats knew what happened, Farragut had won the set 25-8.

The second set was closer at first, but Farragut seemed to overpower Oak Ridge with every serve, kill, or block. The Lady Wildcats brought it to 4-3 before the Lady Admirals went on a 10-3 scoring run to pull the lead to 14-6. After that, Farragut didn’t look back.

After the second set, Coach Carmen Foster huddled her girls up and she told them to calm their nerves.

“Stay together,” Foster encouraged. “Concentrate on the pass, talk to each other out there, and stay positive.” [Read more…]

Filed Under: High School, Slider, Sports, Sports, Top Stories Tagged With: Alex Sherles, Alexis Parker, Anderson County, Anne Abernathy, Bearden, Carmen Foster, Emily Campbell, Emma Milloway, Emma Milstead, Farragut Admirals, Mattie Livengood, Natalie Hartman, Nicholas Rhodes, Oak Ridge Wildcats, Olivia Milloway, Rachel Card, Rachel Loeffler, Raegan Grooms, Region 1, Region 2 Tournament, Region 2-AAA championship, Region 3, Region 4, region tournament, regional championship, Sami Viau, Trenton Duffer, volleyball

ORHS Lady Wildcats undefeated in district play

Posted at 12:47 pm October 1, 2014
By Oak Ridge Today Staff Leave a Comment

Oak Ridge Lady Wildcats Seniors Volleyball

Oak Ridge Lady Wildcats seniors are, from front to back, Rachel Loeffler, Sami Viau, Mattie Livengood, Rachel Card, and Emily Campbell. (Pictures by Loren Bonds)

 

District JV Tournament this afternoon (Oct. 1)

By Head Coach Carmen Foster

The Oak Ridge High School Lady Wildcats (and Baby Cats) played their last district match this past Thursday versus Gibbs High School.

Leading into this match, both the junior varsity and varsity teams were undefeated in district play. A win this past Thursday would cinch the No. 1 seed in the upcoming district tournaments. Both teams won! The Baby Cats won in straight sets and secured the No 1 spot in the JV District Tournament, which will occur this Wednesday, October 1. ORHS is hosting the District JV Tournament starting at 4:30 p.m.

In the follow-up match, the varsity Lady Wildcats won in straight sets against Gibbs: 25-9, 25-12, and 25-8. Gibbs was led by players Morgan Worley with three kills and four digs, and Michaela Wilson with two kills and two digs. [Read more…]

Filed Under: High School, Sports, Top Stories Tagged With: Alex Sherles, Baby Cats, Beth Wyatt, Carmen Foster, Central High School, District III Tournament, District JV Tournament, district tournament, Emily Campbell, Emma Milloway, Gibbs High School, junior varsity, Lady Wildcats, Mattie Livengood, Michaela Wilson, Morgan Worley, Oak Ridge High School, Olivia Milloway, ORHS, Rachel Card, Rachel Loeffler, Reagan Dickens, Sami Viau, Senior Night, Stella Powell, varsity

Lady Wildcats roll over Central in district volleyball match; Senior Night tonight

Posted at 1:50 pm September 25, 2014
By Oak Ridge Today Staff Leave a Comment

Oak Ridge Lady Wildcats Volleyball Timeout

The Oak Ridge Lady Wildcats Volleyball team during a timeout last week against Central. (Submitted photo)

 

By Head Coach Carmen Foster and Assistant Coach Greg Livengood

Last Thursday, the Oak Ridge High School Lady Wildcats and Baby Cats (as we fondly refer to our junior varsity team) took on district rival Central High School. The Lady Cats (both JV and varsity) won in straight sets.

That left both teams undefeated in the district at 6-0.

The Baby Cats came out strong and won in two straight sets: 25-7 and 25-20. [Read more…]

Filed Under: Front Page News, High School, Sports Tagged With: Allison Jones, Baby Cats, Beth Wyatt, Carmen Foster, Central High School, Devyn Bonds, Emily Campbell, Greg Livengood, J.J. Valencia van Booream, Kasey Smith, Lady Wildcats, Mattie Livengood, Mollie Turner, Molly McDonough, Oak Ridge High School, ORHS, Rachel Card, Rachel Clement, Rachel Loeffler, Sami Viau, Sarah Roth, Senior Night, Stella Powell, volleyball

Volley ‘Cats sweep Dragons, 5-0 in district play

Posted at 1:18 pm September 14, 2014
By Oak Ridge Today Staff Leave a Comment

Lady Wildcats Volleyball, Clinton, and Emma and Olivia Milloway

Sisters Emma and Olivia Milloway get a block for the Lady Wildcats against the Clinton Lady Dragons on Thursday. (Photos by Loren Bonds)

 

By Carmen Foster, Head Coach

The Oak Ridge Lady Wildcat volleyball team took on district rival Clinton High School on Thursday night.

The Lady Wildcats beat the Lady Dragons in straight sets: 25-10, 25-22, and 25-15. They were led by seniors Rachel Card (#27), Mattie Livengood (#12), Sami Viau (#3), Emily Campbell (#30), and Rachel Loeffler (#21).

It was a well-played match, with contributions coming from all of the varsity players.

Standouts included seniors: [Read more…]

Filed Under: Front Page News, High School, Sports Tagged With: Alex Sherles, Bearden High School, Carmen Foster, Clinton, Emily Campbell, Emily Lawless, Emma Milloway, Lady 'Cats, Lady Dragons, Lady Wildcats, Mattie Livengood, Oak Ridge, Rachel Card, Rachel Loeffler, Reagan Dickens, Sami Viau, volleyball

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Classifieds

Public Notice: NNSA announces no significant impact of Y-12 Development Organization operations at Horizon Center

AVAILABILITY OF THE FINAL ENVIRONMENTAL ASSESSMENT FOR THE OFFSITE HOUSING OF THE Y-12 DEVELOPMENT … [Read More...]

ADFAC seeks contractors for five homes

Aid to Distressed Families of Appalachian Counties (ADFAC) is a non-profit community based agency, … [Read More...]

Public notice: Draft environmental assessment for Y-12 Development Organization at Horizon Center

AVAILABILITY OF THE DRAFT ENVIRONMENTAL ASSESSMENT FOR THE OFFSITE HOUSING OF THE Y-12 DEVELOPMENT … [Read More...]

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