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ORNL cell-free protein synthesis is potential lifesaver

Posted at 10:47 am January 3, 2016
By Oak Ridge National Laboratory Leave a Comment

Nanoporous-Membrane-December-2015-ORNL

This section of a serpentine channel reactor shows the parallel reactor and feeder channels separated by a nanoporous membrane. At left is a single nanopore viewed from the side; at right is a diagram of metabolite exchange across the membrane. (Image by ORNL)

 

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the U.S. Department of Energy’s Oak Ridge National Laboratory.

The device, a creation of a team led by Andrea Timm and Scott Retterer of the lab’s Biosciences Division, uses microfabricated bioreactors to help the on-demand production of therapeutic proteins for medicines and biopharmaceuticals. Making these miniature factories cell-free, which eliminates the maintenance of a living system, simplifies the process and lowers cost.

“With this approach, we can produce more protein faster, making our technology ideal for point-of-care use,” Retterer said. “The fact it’s cell-free reduces the infrastructure needed to produce the protein and opens the possibility of creating proteins when and where you need them, bypassing the challenge of keeping the proteins cold during shipment and storage.” [Read more…]

Filed Under: Front Page News, Oak Ridge National Laboratory, U.S. Department of Energy Tagged With: Andrea Timm, bioreactor, Biosciences Division, Carmen Foster, Center for Nanophase Materials Sciences, DOE, DOE Office of Science, electron beam, Funding for this project was provided by the Defense Advanced Research Projects Agency, Leidos, microfabricated bioreactors, Mitchel Doktycz, nanoporous membrane, National Institutes of Health, Northwestern University, Oak Ridge National Laboratory, Peter Shankles, photolithography, Scott Retterer, Small, therapeutic proteins, Towards Microfluidic Reactors for Cell-Free Protein Synthesis at the Point-of-Care, U.S. Department of Energy

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