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ORNL: New tool on horizon for surgeons treating cancer patients

Posted at 8:27 pm June 18, 2015
By Oak Ridge National Laboratory Leave a Comment

Droplet-based Surface Sampling Probe

Oak Ridge National Laboratory’s new droplet-based surface sampling probe speeds the process of analyzing a liver biopsy sample. (Photo courtesy ORNL)

 

Surgeons could know while their patients are still on the operating table if a tissue is cancerous, according to researchers from Oak Ridge National Laboratory and Brigham and Women’s Hospital/Harvard Medical School.

In the journal Analytical and Bioanalytical Chemistry, a team led by ORNL’s Vilmos Kertesz describes an automated droplet-based surface sampling probe that accomplishes in about 10 minutes what now routinely takes 20 to 30 minutes. Kertesz expects that time to be cut to four to five minutes soon. For this proof-of-concept demonstration, researchers rapidly profiled two hormones from human pituitary tissue.

“Instead of having to cut and mount tissue and wait for a trained pathologist to review the sample under a microscope, a technician might soon perform an equally conclusive test in the operating environment,” Kertesz said.

The new mass spectrometry-based technology provides an attractive alternative to the traditional method called immunohistochemistry, or IHC, which looks for specific protein biomarkers to make a diagnosis. Although the IHC approach provides a high degree of spatial recognition, it is time-consuming and limited by the quality and specificity of the antibody used to detect the protein. [Read more…]

Filed Under: Front Page News, Oak Ridge National Laboratory, U.S. Department of Energy Tagged With: Aaron Sharp, AB Sciex, Analytical and Bioanalytical Chemistry, anitbody, biomarker, Brigham and Women’s Hospital/Harvard Medical School, cancer, cancer patients, Daniel E. Ponton Fund of the Neurosciences, DFCI Pediatric Low-Grade Astrocytoma Program, DOE, droplet-based method, Gary Van Berkel, IHC, immunohistochemistry, Nathalie Y.R. Agar, National Institutes of Health, Oak Ridge National Laboratory, Organic and Biological Mass Spectrometry Group, ORNL, pituitary tissue, protein biomarker, sampling probe, surgeon, tumors, U.S. Department of Energy, Vilmos Kertesz

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